A recent review suggests that inflammasomes (leucine-rich repeat (LRR)-containing proteins (NLR) family members such as NLRP3, NLRP6, NLRP12, and interferon-inducible protein (AIM2)) may contribute to the development of various diseases associated with cigarette smoke exposure, including COPD. The gene discussed is NLRP6; the disease is chronic obstructive pulmonary disease.