This review will explore antioxidative, Nrf2-involving treatments targeting different risk factors of diabetic dyslipidemia (e.g., VLDL, sdLDL, hepatic lipolysis-stimulated lipoprotein receptor (LSR) impairment), how each of the risk factors causes atherosclerosis, and how the treatments can therefore be used to treat atherosclerosis in patients with DM. The gene discussed is LSR; the disease is atherosclerosis.