NQO1 and Familial prostate cancer: For instance, the activation of the Nrf2/Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1) signaling was shown to induce the activation of the expression of NAD(P)H:quinone oxidoreductase 1 (NQO1), an antioxidant enzyme that protects cells against oxidative stress and inhibits the onset of ovarian cancer [19] and prostate cancer [20].