HAVCR1 and Hepatic fibrosis: To counter bias of KIM-1 homolog expression in the liver, the authors also comprehensively chose to perform single intraperitoneal injections of carbon tetrachloride (CCl4, a known hepatotoxic agent often used to induce hepatic fibrosis [47]) in mice to examine possible plasma KIM-1 changes attributed to (hepatocellular) liver injury.