Furthermore, sKIM-1 on the admission day became a relevant predictor in multivariate analysis for sepsis in patients without known CKD or AKI after 48 h when adjusting for COPD, bilirubin, and platelets (adjusted OR 1.89 [1.03–3.48] per loge increase in KIM-1, p = 0.041, Table 5). This evidence concerns the gene HAVCR1 and chronic kidney disease.