The severity of kidney injury increased the significance level, as patients with a creatinine level of ≥4 mg/dL, equalling KDIGO AKI stage 3 (352.8 vs. 176.4 pg/mL, p = 0.008, Figure 3B), and patients with the need for immediate or later renal replacement therapy (RRT) (299.7 vs. 146.3 pg/mL, p < 0.001, Figure 3C) demonstrated significantly higher KIM-1 serum levels than patients without acute(-on-chronic) kidney injury. Here, HAVCR1 is linked to acute kidney injury.