Previous research has indicated that a singular rare variant in KANK1 and three in KANK2 were associated with minimal change nephrotic syndrome (MCNS), while two rare variants in KANK4 were linked to FSGS [6], aligning with the mild phenotype observed in podocyte-specific Kank1 knockout mice. This evidence concerns the gene KANK2 and focal segmental glomerulosclerosis.