Previous research has indicated that a singular rare variant in KANK1 and three in KANK2 were associated with minimal change nephrotic syndrome (MCNS), while two rare variants in KANK4 were linked to FSGS [6], aligning with the mild phenotype observed in podocyte-specific Kank1 knockout mice. The gene discussed is KANK4; the disease is focal segmental glomerulosclerosis.