Comparably, atherosclerotic AAA tissues from Ang II-infused Apoe−/− mice displayed medial elastin degradation (Figure 1H) which co-localized with elastinolytic activity (Figure 1I) that could be significantly reduced through inhibition of MMP-12 activity with RXP470.1 (Figure 1J,K). This evidence concerns the gene MMP12 and triple-A syndrome.