For example, Aβ-activated astrocytes and microglia secrete various cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukins (IL-1β, IL-6, IL-2, and IL-12), and interferon-gamma (IFN-γ), which promote inflammation in AD [1,12]. The gene discussed is IL2; the disease is Alzheimer disease.