The minor allele of MYD [88] (rs7744) was associated with response to TNFi (OR: 1.24 [95% CI: 1.02–1.51]) across six studies including 3158 patients with psoriasis [24,32] or RA51 [89,90,91], and the minor allele of NLRP3 (rs4612666) was associated with poor response to TNFi (OR: 0.71 [95% CI: 0.58–0.87]) across five studies including 3819 patients with RA [50,51,52] or IBD [30,79]. Here, NLRP3 is linked to inflammatory bowel disease.