TNF and inflammatory bowel disease: The minor allele of TNF-α-308 (rs1800629) was associated with poor response both to TNFi overall (0.71 [95% CI: 0.55–0.92]) across 25 studies including 4341 patients with psoriasis [24,36,37,38], RA [29,62,92,93,94,95,96,97,98,99,100], or IBD [30,82,83,85,86,101,102,103,104] and response to etanercept (0.48 [95% CI: 0.26–0.86]) across seven studies including patients with psoriasis [36,38] and RA [29,93,95,96,98].