Although modulating the p75NTR has been shown to be neuroprotective in aging and AD models, especially in basal forebrain cholinergic cell populations [41,43,44], no previous work has been undertaken to determine if targeting the p75NTR during binge ethanol exposure would protect cholinergic neuronal phenotypes and/or improve long-term neurocognitive outcomes. This evidence concerns the gene NGFR and Alzheimer disease.