TP53 and glioblastoma: Genetic risk factors include inherited disorders such as Li Fraumeni Syndrome, Turcot syndrome, Neurofibromatosis type 1, and several other specific genetic mutations predisposing to the development of GBM: TP53, PTEN, EGFR, NF1 mutations, and chromosomal aberrations such as trisomy of chromosome 7 and monosomy of chromosome 10 [3,4,5].