Diagnosis of IDH-wild-type glioblastoma within the context of an IDH-wild-type diffuse and astrocytic glioma is dependent on the presence of several criteria—microvascular proliferation, necrosis, TERT promoter mutation, EGFR gene amplification, or +7/−10 chromosome copy number changes [22]. The gene discussed is TERT; the disease is glioblastoma.