TP53 and glioblastoma: The most common mutations in GBM tumors are those detected in TP53 (tumor protein 53, frequency of mutation: 31–39%), PTEN (phosphatase and tensin homolog, mutated in 24–37% of tumors), IDH1 (mutated in 12–20%), EGFR (14–15%), and NF1 (neurofibromin 1, 15–17%).