NLRP3 and cancer: Additional factors, including Doublecortin-like kinase 1 (DCLK1) isoform 2 [93], a member of the regenerating islet-derived family REG4 [94], NLR family pyrin domain containing 3 (NLRP3) [95], and Notch signaling pathways [96], also play roles in enhancing M2 polarization and have potential roles in cancer progression.