The intracellular accumulation, along with increased PDI expression in HEK-293T cells of two of the identified ADAMTSL4 variants (p.Arg774Trp and p.Arg98Trp), indicated the induction of ER stress, which is associated with various pathological conditions, including glaucoma [66,67,68,69]. This evidence concerns the gene ADAMTSL4 and glaucoma.