CPAMD8 encodes a protein that is part of the A2M/C3 (alpha-2-macroglobulin/complement 3) protein family [64], which present a broad spectrum of endopeptidase inhibitor activity [65], and is associated with autosomal recessive anterior segment dysgenesis 8 (https://search.clinicalgenome.org/kb/genes/HGNC:23228, accessed on 27 April 2023). The gene discussed is A2M; the disease is anterior segment dysgenesis.