Thus, hepatocellular lesions can arise due to direct viral infection at the hepatocellular level are mediated by the systemic inflammatory response, especially in patients diagnosed with cytokine storm where high concentrations of IL6 and IL1 generate acute hepatocellular injuries, arise due to hypoxia or are caused injuries secondary to drug treatment within the anti-COVID-19 therapeutic protocol [26]. The gene discussed is IL6; the disease is COVID-19.