S100B and major depressive disorder: Many astrocytic molecules (GFAP, Vimentin, ALDH1L1, SOX9, GLUL, SCL1A3, S100B, CX43, CX30, ICAM-1, CNR2, and GPR55) were decreased in the ACC, DLPFC, MD, PMC, PVC, CN, HIPP, LC, and Cb, while the transcription of astroglia-located components of the glutamate–glutamine cycle, EAAT1, EAAT2, and GLUL were decreased in the DLPFC of suicidal MDD patients (Table 2).