GH1 and hypopituitarism: On the other hand, Lanzetta et al. [25] have reported similar effectiveness of rhGH therapy in the patients with definite GHD (confirmed genetic defect, combined pituitary hormone deficiency, anatomical hypothalamic–pituitary abnormality) and with “short stature unresponsive to stimulation” (decreased GH peak in stimulation tests but no identified cause of impaired GH secretion).