Targeted DNA custom epilepsy Next Generation Sequencing (NGS) panel sequencing identified a previously described pathogenic PCDH19 c.1682C>T (p.Pro561Leu) variant in Patient 1, a pathogenic c.1152_1180del (p.Gln385Serfs*6) deletion in Patient 2, which has not been reported, and a known c.1711G>T (p.Gly571Cys) VUS in Patient 3. The gene discussed is PCDH19; the disease is epilepsy.