In turn, Nrf2 activation contributes to the improvement of cognitive performance in aging [23], lipopolysaccharide-induced neuroinflammation [24], D-galactose-induced neurotoxicity [25], high-fat diet [26], drug-induced cognitive impairment [27], streptozotocin-induced Alzheimer’s disease rat models [28], and transgenic APP/PS1 mouse (Alzheimer’s disease model) [29]. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.