The heatmaps revealed an increase in several classic proinflammatory cytokines such as Tnf, Il6, Il1a, Il23α and a small number of chemokines, including Ccl19, Ccl20, Cxcl13, and Cxcl5, which are typically elevated in psoriasis patients, in CD169+ macrophages. This evidence concerns the gene TNF and psoriasis.