This study was designed to elucidate the pharmacological effects of dapagliflozin on cardiac ion channels Kv11.1, Kv1.5, Kv4.3, Kir2.1, K2P2.1, K2P3.1 and K2P17.1 contributing to human atrial K+ currents IKr, IKur, Ito, IK1, and IK2P that represent potential targets for antiarrhythmic AF therapy [14]. Here, KCNK2 is linked to atrial fibrillation.