Fu et al. suggest that NT-proBNP depends on cardiac function in CKD patients with an estimated glomerular filtration rate (eGFR) of 45–60 mL/min/1.73 m2, while for an eGFR < 45 mL/min/1.73 m2, it depends on renal function [18]. The gene discussed is NPPB; the disease is chronic kidney disease.