Although the current data show that elevated NT-proBNP levels in pre-dialysis and dialysis patients mainly indicate cardiovascular disease and are linked to the risk of future cardiovascular events in CKD [63,64,65], the diagnostic value of elevated NT-proBNP provides moderate or no prediction of heart failure in CKD patients, especially in advanced stages [66,67]. The gene discussed is NPPB; the disease is heart failure.