The apparent contradiction between pro-inflammatory and anti-inflammatory mechanisms could be explained by the fact that COR-TP would be formed to a greater extent in the tumor microenvironment, whereas in the rest of the body, it would remain in its non-phosphorylated and deaminated form (3′-dINO), having anti-inflammatory effects by the exact immunosuppressive mechanisms of the deaminated form of ADO (INO), since it has been proven that INO can weakly activate adenosine A2A receptors [88], and presenting anti-inflammatory effects [89]. The gene discussed is ADO; the disease is neoplasm.