Notably, RV was able to convert the phenotype of HDFa and HFF-1 cells (which basally display a low level of autophagy and an upregulated expression of FAP and α-SMA) into an NF-like phenotype and, more importantly, prevented their activation into CAFs when exposed to ovarian cancer cell-conditioned medium. The gene discussed is ACTA1; the disease is ovarian carcinoma.