Moreover, it was also shown that EV-A71 infection induces a caspase-3-dependent degradation of cellular karyopherin-α1 (KPNA1), a nuclear localization signal receptor for phosphorylated STAT1, which in turn inhibits the transportation of phosphorylated STAT1/2 into the nucleus where they drive the expression of hundreds of ISGs [112]. This evidence concerns the gene STAT1 and infection.