SIRT1 and metabolic disease: MiR-17-5p has been linked to at least 1181 target genes associated with metabolic disease, including neuronal differentiation 1 (NEUROD1), leptin (LEP), leptin receptor (LEPR), uncoupling protein 3 (UCP3), sirtuin 1 (SIRT1), peroxisome proliferator activated receptor α (PPARA), and low-density lipoprotein receptor (LDLR) [33].