Mechanistic investigations have pointed to the involvement of miR-222-3p levels in T2D, supported by its targeting of genes like O-6-Methylguanine-DNA Methyltransferase (MGMT), protein phosphatase 2 regulatory subunit B-α isoform (PPP2R2A), and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) associated with T2D pathology [32,48,49]. This evidence concerns the gene PPP2R2A and type 2 diabetes mellitus.