ICAM1 and neoplasm: At an increased concentration, CBD has been shown to significantly decrease the size of xenografted tumours and metastatic nodules through ICAM-1 and TIMP-1 (tissue inhibitor of metalloproteinases 1) as the key molecular targets of the anti-invasive mechanism of CBD [33,37], preventing cancer cell adhesion to non-cancer cells and reducing cell invasion and metastasis.