EDN1 and neoplasm: Briefly, the in vitro and in vivo anti-angiogenic properties of CBD were associated with the receptor-mediated down-modulation of several angiogenesis-associated molecules, such as MMP2 and MMP9, endothelin-1 (ET-1), platelet-derived growth factor-AA (PDGF-AA), as well as the inhibition of the hypoxia-inducible transcription factor HIF-1α, one of the most critical stimuli for cell survival, motility, and tumour angiogenesis [4,23,41].