TNFRSF10B and central nervous system cancer: A study by Ivanov and co-workers [32] showed that CBD, in a similar fashion to glioma cancer treatments such as ɣ-irradiation, leads to the substantial upregulation of TNF/TNFR1 and TRAIL/TRAIL-R2 signalling along with the death receptor (DR5) within the extrinsic apoptotic pathway as one of multiple cell death-inducing signalling mechanisms of CBD in human glioblastoma.