In light of the evidence suggesting the involvement of the PI3K/AKT/mTOR pathway in GBM, Eckerdt and colleagues [82] evaluated the impact of dual PI3K/mTOR pathway inhibition in GBM and GSCs, in which simultaneous mTOR inhibition was found to potentiate the antineoplastic effects of PI3Kα inhibition. Here, AKT1 is linked to glioblastoma.