CNR1 and central nervous system cancer: For instance, the CBD-induced pro-apoptotic mechanisms in glioma and pancreatic cancer are both a result of the CB1 and CB2 perception of the compound, which is followed by ceramide synthesis, induced ER stress, and the upregulation of p8–TRIB3, which leads to Akt inhibition and subsequent autophagy to enable apoptosis [19,73].