A later study from the same colleagues further shed light on the potential mechanisms of eCBNs in anti-prostate cancer activity; here, the authors revealed that the activation of CBN receptors with the eCBN 2-Arachidonoylglycerol (2-AG) in PC-3 cell lines promotes the PI3K/Akt pathway and the subsequent activation of the Raf-1/ERK1/2 signalling pathway [65], which represents the first look at the molecular mechanism of these activities. Here, MAPK3 is linked to prostate cancer.