These proposed novel mechanisms were revealed from the treatment of A549 and H460 NSCLC lines and primary lung tumour cells with CBD, which induced the upregulation of COX-2, followed by elevations of COX-2-derived PGE2, PGD2, and 15dPGJ2, leading to apoptotic cell death. This evidence concerns the gene PTGS2 and non-small cell lung carcinoma.