The anti-proliferative effect from the activation of PPAR-γ is fulfilled by the subsequent ablation of cyclin D1 (a family of positive regulators for cell progression) and the blocking of the mTOR signalling pathway, which leads to the downregulated proliferation, migration, and invasion of breast cancer cells, as well as the upregulation of apoptosis and autophagy [48]. Here, CCND1 is linked to breast cancer.