Furthermore, we analyzed the impact of decreased SPTAN1 expression on key molecular processes of tumor progression by examining the Rat sarcoma (RAS)-mediated rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular-signal-regulated kinase (RAF/MEK/ERK) pathway, which has emerged as a potential inducer of EMT. Here, SPTAN1 is linked to neoplasm.