IFN-γ disrupts the immune privilege of HFs, which is typically maintained during the anagen phase through downregulation of MHC class I molecules and upregulation of inhibitors of NK and CD8+ cells, such as macrophage migration inhibitory factor (MIF) and transforming growth factors (TGF) β1 and β2 [112,120]. The gene discussed is CD8A; the disease is Hand-foot syndrome.