There is evidence that nuclear receptors can be activated or become dysfunctional in MASLD, as found for the bile acid (BA) receptor farnesoid X receptor (FXR) [102,103], the liver X receptor (LXR) [104], the pregnane X receptor (PXR) [105], and the vitamin D receptor (VDR) [106]. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatotic liver disease.