Single nucleotide polymorphisms (SNPs) in genes involved in insulin resistance have also been described in individuals with MASLD, including the genes of “ectoenzyme nucleotide pyrophosphate phosphodiesterase 1” (ENPP1 or PC1) and “insulin receptor substrate-1” (IRS1) [49]. The gene discussed is ENPP1; the disease is metabolic dysfunction-associated steatotic liver disease.