Some of the more well-characterized VCP OMM target proteins identified to date include the mitochondrial fusion proteins MFN1 [61,62] and MFN2 [62], the E3 ubiquitin ligase membrane-associated ring finger (C3HC4) 5 (MITOL/March5) [64], the apoptosis regulators myeloid cell leukemia 1 (MCL1) [61,65], Bcl-2 related ovarian killer (BOK) [66] and solute carrier family 25 member 46 (SLC25A46), a protein linked to hereditary motor and sensory neuropathy and pontocerebellar hypoplasia [67]. The gene discussed is SLC25A46; the disease is sensory peripheral neuropathy.