SOD1 and amyotrophic lateral sclerosis: To further molecularly characterize whether the antibody cocktail can recognize ALS-linked SOD1 mutants with distinct biopsychical properties and conformations, we used seven different types of the mutants classified into three groups: (i) WT-like mutants, G37R [7], D90A [36], and G93A [37]; (ii) dimer interface mutants, A4V [38] and I113T [39]; and (iii) metal binding region mutants, H46R and G85R [7,40] (Figure 3A).