SOD1 and amyotrophic lateral sclerosis: Although each of these antibodies fails to recognize ALS-linked SOD1 mutants with a point mutation in their epitope region (amino acids 8–14 for MS785; amino acids 30–40 for MS27), the use of an MS785 and MS27 cocktail compensates for each of their shortcomings, with this mixture recognizing over 100 ALS-linked SOD1 mutants, as determined by immunoprecipitation [27].