SOD1 and amyotrophic lateral sclerosis: So far, over 30 causative genes have been identified in familial ALS [2], one of which is the gene encoding superoxide dismutase-1 (SOD1); mutations in this gene contribute to approximately 20% of familial cases [3] and more than 200 mutations have been found, which are collated in the ALSoD genetic database (http://alsod.iop.kcl.ac.uk/, accessed on 25 March 2024).