- gene CLDN11, chromosome 3 (human), 3 (mouse)- mRNA/protein: very high expression in BEC (human, mouse, rat) in vivo equal to Cldn5, in vitro strongly down-regulated [50,130]- less expressed in human brain oligodendrocytes [50]- KO mouse: mild neurological deficits [131], deafness (low endocochlear potential) [47]- KD: enhanced dextran permeability through BEC layers [130]. The gene discussed is CLDN11; the disease is deafness.