- reduced in multiple sclerosis [130]- decreased in EAE by activated annexin A2 signalling (brain capillaries) [134]- decrease in BEC by podocalyxin KD [135]- increased in blood of human autism spectrum disorder [126]- ischemia reduces Cldn11; KO of leucine-rich alpha-2 glycoprotein 1 improves Cldn11 and BBB in ischemia [132]. Here, LRG1 is linked to multiple sclerosis.