- GPR30 via ERK and/or Akt-domain [89]- dehydroepiandrosteron/Gnα11 [90]- hypoxia inducible factor-complex [91]- cAMP/PKA, down-regulation and cytosolic localisation [92]- down-regulated by hypoxia, focal cerebral ischemia [50], glioblastoma [93]- down-regulated by TGFβ [93], Cu [94], miR212/132 [95]- differentiated regulation upon virus infection [96,97,98,99,100]. This evidence concerns the gene AKT1 and glioblastoma.