For example, ACE overexpression in myeloid-derived cells has been shown to increase the production of pro-inflammatory cytokines, such as IL-12β, TNF, or nitric oxide, while ACE overexpression in neutrophils has been shown to increase resistance to infections with MRSA, Klebsiella pneumoniae, and Pseudomonas aeruginosa [40]. The gene discussed is ACE; the disease is infection.