Likewise, treatment of human astrocytes with exogenous DPRs led to mis-splicing of EAAT2 [74], recapitulating what was previously observed in ALS patient tissue [68]; however, a separate study found that DPRs directly bind to the EAAT2 mRNA but were unable to reproduce the splicing defect [75]. The gene discussed is SLC1A2; the disease is amyotrophic lateral sclerosis.