NFATC2 and neoplasm: However, abundant lactate impedes the anti-tumor effects of cytotoxic T lymphocytes (CTLs) by blocking the import transporter MCT-1 while enhancing Tregs by facilitating NFAT1 translocation into the nucleus and augmenting lactate absorption via the upregulation of MCT-1 and lactate dehydrogenase A (LDHA) expression [20].