ROCK2 and glaucoma: Goldhagen et al. proved that both normal and glaucoma human eyes showed positive immunohistochemical staining for RhoA, ROCK-1, and ROCK-2 in the TM, CM, and optic nerve head (ONH), and there was a significant increase in the RhoA protein levels in the glaucomatous ONH compared to the age-matched control group [28].