CDH1 and neoplasm: Recent studies have highlighted the impact of the EMT process on the anti-tumor efficacy of NK cells, particularly emphasizing the role of E-cadherin expression in NK cell-mediated cytotoxicity [30] Additionally, the Wnt/β-catenin signaling pathway is known to be significantly activated in highly invasive metastatic breast tumor cell lines, with an overactive pathway correlating with poor clinical prognosis [31,32,33,34].