We collected reported genetic polymorphisms in the ORF of the SPRN gene in prion disease-susceptible animals (humans [26,42], cattle [15,43,44,45], sheep [28,42,44], goats [27,44,46]), and prion disease-resistant animals (dogs [47], horses [48,49], chickens [50], and ducks (this study) to compare the distribution of SNPs between these two groups (Figure 6). This evidence concerns the gene SPRN and prion disease.