Data in GSE83448 [56] also showed reduced PLCB3 mRNA expression in adult ileal CD patients (Figure S9B) and data in GSE179285 [57] showed reduced PLCB3 mRNA more strongly in inflamed than in uninflamed terminal ileum of adult CD, but not in colonic CD or ulcerative colitis patients (Figure S9C). The gene discussed is PLCB3; the disease is Cowden disease.