Like TAMs, tumor-associated neutrophils (TANs) impair antitumor immunity, stimulate angiogenesis, and accelerate tumor growth, invasion, and ultimately metastasis by remodeling the ECM and producing growth factors, including VEGF, a variety of cytokines, and chemokines such as IL-17 and MMP9, as well as the high mobility group box 1 [102,103,104]. Here, HMGB1 is linked to neoplasm.