Interestingly, in addition to exhibiting typical MEN1 endocrine tumors, these patients also developed melanoma, suggesting that MEN1 is a strong candidate gene for familial malignant melanoma (for families in which 2 or more first-degree relatives, such as a parent, sibling, and/or child, exhibit skin cancer) [24,52]. The gene discussed is MEN1; the disease is skin neoplasm.