Although hypoxia-inducible factor manipulation has been extensively studied, but has been only modestly successful in tumor regression [69], several recent findings have suggested that manipulating downstream genes, such as GPRC5A [70], might induce apoptosis in cancer cells by inactivating the GPRC5A-YAP-Bcl2L1 pathway. The gene discussed is BCL2L1; the disease is neoplasm.