One study showed that hypoxia can induce an embryonic-stem-cell-like transcriptional program, including the iPSC inducers Oct4, Sox2, c-Myc, Klf4, Nanog, and microRNA-302, in 11 cancer cell lines from the prostate, brain, kidneys, cervix, lungs, colon, liver, and breasts [24]. The gene discussed is KLF4; the disease is cancer.