IL-8 affects proliferation, migration, invasion, and mobility of cancer cells, and may induce morphological and molecular changes associated with EMT by changes in shape from cuboidal to spindle, actin cytoskeleton remodeling, upregulation of vimentin, and downregulation of E-cadherin in lung carcinoma cells [6,7,38]. This evidence concerns the gene CXCL8 and cancer.