C9orf72 and amyotrophic lateral sclerosis: BIX-01294, which inhibits the euchromatic histone-lysine N-methyltransferase 2 (RHMI2 or G9A), responsible for H3K9 methylation, was tested in an in vitro assay and reported to inhibit the repeat associated non-AUG (RAN) translation of the C9ORF72 repeat expansion associated with ALS/FTD [125].