DNMT3A and amyotrophic lateral sclerosis: Finally, in the SOD1G93A and SOD1G37R mouse models of ALS, DNMT1 and DNMT3A protein levels and binding to chromatin as well as global DNMT enzymatic activity were reported increased both in spinal cord and skeletal muscle and were accompanied by increased 5mC levels in MN and satellite cells of the skeletal muscle [57].