APP and early-onset autosomal dominant Alzheimer disease: In various mouse models, including amyloid protein precursor (APP) transgenic mice (6 J/cm2) [62], Aβ-induced Alzheimer’s disease (AD) mice (3 J/cm2) [60], and a major depression (41 J/cm2) mouse model [59], cerebral ATP levels were augmented utilizing transcranial PBM therapy with an 808 nm laser.