Future work will help to clarify how immunotherapy affects (1) the balance between bystander T cells, presumed to comprise a diverse array of clonotypes within the TME of NMSCs [105], tumor-specific resident clonotypes of exhausted CD8 T cells, and incoming new clonotypes of CD8 T cells, and (2) the dynamics between intra-tumoral and stromal TILs. Here, CD8A is linked to neoplasm.