Also, increased levels of markers such as TIGIT, Nrp-1, neurogenic locus notch-homolog protein 1 (Notch-1), T cell immunoglobulin and mucin domain 3 (TIM-3), B-lymphocyte-induced maturation protein 1 (BLIMP-1) and others (shown in Table 5) also contribute to enhanced Treg activity and the promotion of tumor growth. The gene discussed is NOTCH1; the disease is neoplasm.