A study revealed a close association between CSCs and EMT, indicating EMT as a probable mechanism for tumor invasion and metastasis, while identifying CD44+/α2βhi1/CD133+ prostate cancer and CD133+/CXCR4+ pancreatic cancer cells as tumorigenic, highlighting the critical role of CSCs in tumor progression and metastasis [57]. This evidence concerns the gene PROM1 and Familial prostate cancer.