A small percentage of colorectal cancer is inheritable, where germline mutations are found in the genes coding for the adenomatous polyposis coli (APC) (Gardner’s syndrome), the tumor suppressor LKB1 (Peutz–Jeghers syndrome), DNA repair proteins MLH1, MSH2, MSH6, PMS2, EPCAM, and MUTYH (Lynch’s syndrome), and cystic fibrosis transmembrane conductance regulator CFTR (cystic fibrosis) [5,6,7]. The gene discussed is APC; the disease is Gardner syndrome.