As such, when macropinocytosis and ferroptosis and their associated cellular pathways are compared between the isogenic cell lines HCT-116 and HCT-116/p53 KO, the observed differences are most likely due to the presence or absence of functional p53 in a colon cancer cell line on the background of an oncogenic KRAS mutation and an active β-catenin signaling pathway. This evidence concerns the gene TP53 and colonic neoplasm.