CTHRC1 and systemic lupus erythematosus: Apart from its documented involvement in cardiovascular disease, cancer, and RA, an expanding body of research also associates CTHRC1 with fibrotic conditions such as systemic lupus erythematosus, muscular dystrophies, and fibrosis in the lung, heart, liver, and skin [20,72,76,77,78,79,80,81].