Investigations of specific patients with Ssc-ILD have indicated that the disease is driven by repetitive epithelial injury, leading to varied inflammatory responses that may foster a profibrotic environment and cytokine milieu characterized by the expression of TGF-β, connective tissue growth factor (CTGF), platelet-derived growth factor (PDGF), and interleukins (ILs), such as IL-6 [48,49]. The gene discussed is CCN2; the disease is interstitial lung disease.