LGR5 and fibrosis: In dermal tissues from SSc patients and skin tissues from mice with bleomycin-induced fibrosis, CTHRC1 expression, along with the expression of POSTN and other pathological ECM components, was elevated in a fibroblast subset marked by leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) and associated with SSc pathology [97].