UDP-Glucose-4-Epimerase (GALE, log2FC = −5.68, FDR = 2.78 × 10−2), Inter-Alpha-Trypsin Inhibitor Heavy Chain 1 (ITIH1, log2FC = −3.91, FDR = 7.19 × 10−5), and Glycoprotein M6A (GPM6A, log2FC = −1.23, FDR = 2.08 × 10−3) were the top three down-regulated proteins in COPD BALF EVs. Here, ITIH1 is linked to chronic obstructive pulmonary disease.