Conversely, in COPD EVs, Apolipoprotein E (APOE) exhibited a negative correlation with macrophage numbers (r = −0.49, p = 0.04), while Aquaporin1 (AQP1) showed a positive correlation (r = 0.51, p = 0.03) with macrophage numbers. Here, AQP1 is linked to chronic obstructive pulmonary disease.