IDH2 and central nervous system cancer: The importance of the NADP(+)-dependent isocitrate dehydrogenases protein encoded by IDH1 and IDH2 genes has been known for over a decade, whereby IDH1 mutations are present in high-grade gliomas that develop from low-grade gliomas, whereas IDH-wildtype GBMs arise de novo and usually have a poorer prognosis [5,10].